Perbandingan interferon Gamma terhadap Antigen Rekombinan Tuberkulosis dengan Skin test pada Perawat di RSUP dr. Sarjito, Yogyakarta

Jurusan Keperawatan Poltekkes Kemenkes Yogyakarta

2015-02

en

Article

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The disease Tuberculosis (TB)is caused by Mycobacterium Tuberculosis (M.tuberculosis. M.tuberculosis has infected a third of the world population. Transmissionof TB in the form of droplets (splash sputum). People can become infected if the droplets are inhaled. Nurses are part of health teams at risk of contracting TB. Detection ofTB infection is contact with Skin Test (Skin Test Tuberculin / TST), andmeasuring levels of interferon gamma (IFN-y) after stimulation of various antigens in TB. The purpose of this study to determine the prevalence of TB infection in nursing contacts of different wards, long of work and history contacts. Thisis the type of quantitative research with cross sectionaldesign. The results showed than 30 nurses with age 28-56 years (average 42 years), 13 of risk wards and 17 of the wards are not at risk. 4 sex male (13.33%) and 26 female (86.67%), with an average age of 42.4 years. Test the difference between Skin Test with IFN-y showed no significant differences of several antigens as a stimulus measure with Kappa test for both measurements showed that the antigen Ag85 has the highest value with 66.67% – 55.33% agreement valueKappa; 0.253. Positive results with Skin Test is 30%, positive by IFN-y levels were 36.66% and positive by the second measurement is 16.66%. The ward with the outcome variables Skin tests showed significant relationships, but the results of IFN-y is not significant. ThishappensbecauseofsomethingtodowithahistoryofB Cvaccination,and subjects residing in the ward at risk not only care for TB patients but also caring for patients with various diseases, so the possible contacts with other mycobacterium. Working Old with variables Skin Test and IFN-y showed no significant relationship, the frequency distribution of skin test results and levels of IFN-y was higher in the Old Work risky. History contact variables Skin with the Test and IFN-y showed no significant relationship, the frequency distribution of skin test results and levels ofIFN-y was higheri n Contact Historyrisky. Conclusion This study shows that both measurements both Skin Test and IFN-y is not statistically differ, each has an equal role in showing the risk factors, a quantitative IFN-y is superior. In particular, this study did not discuss the B C vaccination, because all subjects had the BCG vaccination.The second difference measurements showed that the skin test and IFN-y is not statistically differ, each has advantages and limitations, have an equal role in showing theriskfactors, the quantity ofIFN-y is superior.