ADVANTED OF SARANG SEMUT INFUSION (Myrmecodia pendens Merr & Perry) AS DECREASED BLOOD’S URIC ACID IN MALE RATS OF WISTAR STRAIN

2017-11-05

en

Conference or Workshop Item

text

Hyperuricemia is a condition of high levels of uric acid in the blood. Hyperuricemia can occur on the accumulation of uric acid crystals in the joints, causing pain. To overcome the problem of hyperuricemia can be done by decrease uric acid levels using herbal medicine is sarang semut (Myrmecodia pendens Merr & Perry). The aims of this research was to determine the effect extract of sarang semut on blood uric acid levels in male rats were made hyperuricemia with potassium oxonate and to find the effective dose. This research is experimental in vivo in male rats of Wistar strain. Using 30 rats were divided into 6 treatment groups, normal control group, positive control (allopurinol 12.6 mg), negative control, and sarang semut extract dose 200 ; 400 and 800 mg. Induction of uric acid is done by giving potassium oxonate 250 mg intraperitoneally. Measurement of levels of uric acid perfomed on the firts day (pre-treatment and post-treatment) and seventh day. Results of statistical test of this research showed that the extract of sarang semut in three ranks doses produce blood uric acid levels decreased significantly (p<0,05) compared to the negative control. If viewed from the percent dose reduction to 200 ; 400 and 800 mg, respectively 77.73% ; 134.97% and 81.64%. Decrease levels of uric acid in the three doses presumably because it contains flavonoids that act to inhibit xanthine oxidase into uric acid. From these results it can be concluded that the sarang semut extract can decrease blood uric acid levels and obtained effective dose of 200 mg. Keywords : Uric Acid, Sarang Semut (Myrmecodia Pendens Merr & Perry), Xanthine Oxidase, Male Rats Of Wistar Strain