JUS SELEDRI (APIUM GRAVEOLENS) MENURUNKAN TEKANAN DARAH TIKUS RATTUS STRAIN WISTAR DENGAN HIPERTENSI

POLITEKNIK KESEHATAN KEMENTERIAN KESEHATAN

2014-03

en

Article

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Hypertension is a common public health problem. Uncontrolled hypertension can lead to degenerative diseases, such as congestive heart failure, kidney failure, and vascular disease. Althoug not curable, prevention and appropriate treatment can reduce the incidence of hypertension and accompanying diseases. The study aims to determine the effect of celery juice (Apium graveolens) on systolic blood pressure of Wistar rat ( Rattus Strain) with NaCl-induced hypertention. The study was a true experimental study with pre – post tes with control design.The study enrolled 18 Rattus Wistar strain devided into tree groups were experiment 1 (6 rats), experiment group 2 (6 rats) and control group (6 rats). Sampling technisque used random sampling. Celery juice in experimental animals given twice daily at 10:00 and 15:00 for two weeks. In treatmet group 1 celery juice given 0.009 gram/grams of weight, in treatment group 2 given 0.0225 grams/ grams of weight, while control group given distilled water ad libium. Data were analyzed by one – way ANOVA test. This study found a decrease in mean of systolic blood pressure in treatment group 1 and 2 in the first and second week (post- test) after administration of celery juice, whereas in the control group tended to increase. Conclusion: there is a decrease effect of systolic blood pressure to Rattus strain Wistar with hypertension NaCl – induced given celery juice. Keyword: celery juice, hypertension, Wistar strain rattus.