Dragon Fruit Stem Extract Reduces IgG Levels in Pregnant Wistar Rats as an Immunomodulator Candidate

Poltekkes Kemenkes Yogyakarta

2025-03-05

eng

info:eu-repo/semantics/article

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Dragon fruit stem contains many organic acids, proteins, minerals such as potassium, magnesium, calcium and iron, vitamin C, and sources of antioxidants that have properties to lower blood pressure and blood sugar levels and increase immune system activity. Objective: To analyze the extract of dragon fruit stems from Pelaihari in reducing IgG levels in Pregnant Female Wistar Rats as Immunomodulator Candidates. Method: The research design used experimental. This study on test animals, mice were divided into 5 groups, namely the normal control group, negative control (injected with 10% SDMD antigen), pregnant mice were injected with 10% SDMD antigen + dragon fruit stem extract 500mg, 1000mg and 2000 mg-KgBW-day for 20 days, after which IgG were examined. blood samples were examined, TBARS test analysis, and One Way Anova test analysis. Results: There was an effect of dragon fruit extract on reducing IgG levels in pregnant mice (p<0.05). Doses of 1000mg and 2000mg dragon fruit extract have the ability to decrease IgG levels in pregnant mice, especially at a dose of 2000 mg-KgBW-day. Conclusion: Dragon Fruit plant stem extract can reduce IgG and improve the immune system in pregnant female mice